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1

Fundamental Link between Folding States and Functional States of Proteins

Kalbitzer, Hans Robert, Spoerner, Michael, Ganser, Petra, Hozsa, Constantin, Kremer, Werner

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

2

Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe

Ina C. Rosnizeck, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R. Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer

Journal:

Angewandte Chemie

Year:

2010

Language:

german

File:

PDF, 635 KB

german, 2010

3

Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes

Ina C. Rosnizeck, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R. Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 649 KB

english, 2010

4

ChemInform Abstract: Synthesis of New Water-Soluble Cholesterol Derivatives.

Florian Schmidt, Michael Spoerner, Hans Robert Kalbitzer, Burkhard Koenig

Journal:

Year:

2012

File:

PDF, 30 KB

2012

5

Conformational states of human H-Ras detected by high-field EPR, ENDOR, and 31P NMR spectroscopy

Michael Spoerner, Thomas F. Prisner, Marina Bennati, Melanie M. Hertel, Norbert Weiden, Thomas Schweins, Hans Robert Kalbitzer

Journal:

Magnetic Resonance in Chemistry

Year:

2005

Language:

english

File:

PDF, 212 KB

english, 2005

6

Zinc(II)cyclen–peptide conjugates interacting with the weak effector binding state of Ras

Florian Schmidt, Ina C. Rosnizeck, Michael Spoerner, Hans Robert Kalbitzer, Burkhard König

Journal:

Inorganica Chimica Acta

Year:

2011

Language:

english

File:

PDF, 707 KB

english, 2011

7

Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPγS

Michael Spoerner, Andrea Nuehs, Christian Herrmann, Guido Steiner, Hans Robert Kalbitzer

Journal:

Year:

2007

Language:

english

File:

PDF, 383 KB

english, 2007

8

Kinetic determination of the GTPase activity of Ras proteins by means of a luminescent terbium complex

Christian Spangler, Corinna M. Spangler, Michael Spoerner, Michael Schäferling

Journal:

Analytical and Bioanalytical Chemistry

Year:

2009

Language:

english

File:

PDF, 238 KB

english, 2009

9

Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R

Timo Sieber, Roland Scholz, Michael Spoerner, Frank Schumann, Hans Robert Kalbitzer, Thomas Dobner

Journal:

Year:

2011

Language:

english

File:

PDF, 1.65 MB

english, 2011

10

Metall-Bis(2-picolyl)amin-Komplexe als Zustand-1(T)-Inhibitoren für aktiviertes Ras-Protein

Dr. Ina C. Rosnizeck, Priv.-Doz. Dr. Michael Spoerner, Tobias Harsch, Dr. Sandra Kreitner, Dr. Daniel Filchtinski, Prof. Dr. Christian Herrmann, Dr. Daniel Engel, Prof. Dr. Burkhard König, Prof. Dr. D

Journal:

Angewandte Chemie

Year:

2012

Language:

german

File:

PDF, 622 KB

german, 2012

11

Metal–Bis(2-picolyl)amine Complexes as State 1(T) Inhibitors of Activated Ras Protein

Dr. Ina C. Rosnizeck, Priv.-Doz. Dr. Michael Spoerner, Tobias Harsch, Dr. Sandra Kreitner, Dr. Daniel Filchtinski, Prof. Dr. Christian Herrmann, Dr. Daniel Engel, Prof. Dr. Burkhard König, Prof. Dr. D

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 753 KB

english, 2012

12

A novel mechanism for the modulation of the Ras-effector interaction by small molecules

Michael Spoerner, Thorsten Graf, Burkhard König, Hans Robert Kalbitzer

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 456 KB

english, 2005

13

Rapid assignment of solution 31P NMR spectra of large proteins by solid-state spectroscopy

Adriana Iuga, Michael Spoerner, Christian Ader, Eike Brunner, Hans Robert Kalbitzer

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 139 KB

english, 2006

14

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

Michael Spoerner, Alfred Wittinghofer, Hans Robert Kalbitzer

Journal:

Year:

2004

Language:

english

File:

PDF, 380 KB

english, 2004

15

Solid-state 31P NMR Spectroscopy of Microcrystals of the Ras Protein and its Effector Loop Mutants: Comparison Between Crystalline and Solution State

Adriana Iuga, Michael Spoerner, Hans Robert Kalbitzer, Eike Brunner

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 338 KB

english, 2004

16

Growth and Thallus Morphogenesis of Ulva mutabilis (Chlorophyta) Depends on A Combination of Two Bacterial Species Excreting Regulatory Factors

Spoerner, Michael, Wichard, Thomas, Bachhuber, Tanja, Stratmann, Johannes, Oertel, Wolfgang

Journal:

Journal of Phycology

Year:

2012

Language:

english

File:

PDF, 1.86 MB

english, 2012

17

Solid-State 31 P NMR Spectroscopy of Precipitated Guanine Nucleotide-Binding Protein Ras in Complexes with Its Effector Molecules Raf Kinase and RalGDS

Ader, Christian, Spoerner, Michael, Kalbitzer, Hans Robert, Brunner, Eike

Journal:

Journal of Physical Chemistry B

Year:

2007

Language:

english

File:

PDF, 94 KB

english, 2007

18

Cu 2+ -cyclen as Probe to Identify Conformational States in Guanine Nucleotide Binding Proteins

Meierhofer, Tanja, Rosnizeck, Ina C., Graf, Thorsten, Reiss, Kerstin, König, Burkhard, Kalbitzer, Hans Robert, Spoerner, Michael

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 985 KB

english, 2011

19

Conformational States of Ras Complexed with the GTP Analogue GppNHp or GppCH 2 p: Implications for the Interaction with Effector Proteins †

Spoerner, Michael, Nuehs, Andrea, Ganser, Petra, Herrmann, Christian, Wittinghofer, Alfred, Kalbitzer, Hans Robert

Journal:

Year:

2005

Language:

english

File:

PDF, 248 KB

english, 2005

20

Look, Snap, See: Visual Literacy through the Camera

Thomas M. Spoerner

Journal:

Year:

1981

Language:

english

File:

PDF, 1.78 MB

english, 1981

21

Conformational States of ADP Ribosylation Factor 1 Complexed with Different Guanosine Triphosphates As Studied by 31 P NMR Spectroscopy

Meierhofer, Tanja, Eberhardt, Maren, Spoerner, Michael

Journal:

Year:

2011

Language:

english

File:

PDF, 2.03 MB

english, 2011

22

Structure of the Metal−Water Complex in Ras·GDP Studied by High-Field EPR Spectroscopy and 31 P NMR Spectroscopy ‡

Rohrer, Martin, Prisner, Thomas F., Brügmann, Oliver, Käss, Hanno, Spoerner, Michael, Wittinghofer, Alfred, Kalbitzer, Hans Robert

Journal:

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

23

Elucidating the Mode of Action of a Typical Ras State 1(T) Inhibitor

Rosnizeck, Ina C., Filchtinski, Daniel, Lopes, Rui Pedro, Kieninger, Bärbel, Herrmann, Christian, Kalbitzer, Hans Robert, Spoerner, Michael

Journal:

Year:

2014

Language:

english

File:

PDF, 2.74 MB

english, 2014

24

Structural insights into the small G-protein Arl13B and implications for Joubert syndrome

Miertzschke, Mandy, Koerner, Carolin, Spoerner, Michael, Wittinghofer, Alfred

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 2.91 MB

english, 2014

25

Synthesis of New Water-Soluble Cholesterol Derivatives

Schmidt, Florian, Spoerner, Michael, Kalbitzer, Hans Robert, König, Burkhard

Journal:

Synthetic Communications

Year:

2011

Language:

english

File:

PDF, 249 KB

english, 2011

26

A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins

Jank, Thomas, Bogdanović, Xenia, Wirth, Christophe, Haaf, Erik, Spoerner, Michael, Böhmer, Kira E, Steinemann, Marcus, Orth, Joachim H C, Kalbitzer, Hans Robert, Warscheid, Bettina, Hunte, Carola, Akt

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.57 MB

english, 2013

27

Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy

Kalbitzer, Hans Robert, Rosnizeck, Ina C., Munte, Claudia E., Narayanan, Sunilkumar Puthenpurackal, Kropf, Veronika, Spoerner, Michael

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

28

Crystal Structure of a Schistosoma mansoni Septin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide

Zeraik, Ana E., Pereira, Humberto M., Santos, Yuri V., Brandão-Neto, José, Spoerner, Michael, Santos, Maiara S., Colnago, Luiz A., Garratt, Richard C., Araújo, Ana P. U., DeMarco, Ricardo

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.98 MB

english, 2014

29

Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, H. R., Wittinghofer, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 1.87 MB

english, 2001

30

Improved Binding of Raf to Ras{middle dot}GDP Is Correlated with Biological Activity

Kiel, C., Filchtinski, D., Spoerner, M., Schreiber, G., Kalbitzer, H. R., Herrmann, C.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 3.25 MB

english, 2009

31

Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis

Spoerner, M., Hozsa, C., Poetzl, J. A., Reiss, K., Ganser, P., Geyer, M., Kalbitzer, H. R.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

32

Check Boxes Are No Substitute for Narrative Documentation

Journal:

American Journal of Critical Care

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

33

Intrinsische allosterische Hemmung von Signalproteinen durch Stabilisierung gering besetzter, durch Hochdruck-NMR-Spektroskopie nachweisbarer Interaktionszustände

Kalbitzer, Hans Robert, Rosnizeck, Ina C., Munte, Claudia E., Narayanan, Sunilkumar Puthenpurackal, Kropf, Veronika, Spoerner, Michael

Journal:

Angewandte Chemie

Year:

2013

Language:

german

File:

PDF, 1.20 MB

german, 2013

34

2015 Health Physics Society Honor Roll –James J. “Jim” Thompson

Mickey, Walen, Langley, Karen, Hoover, Mark, Potter, Charles A., Enghauser, Michael, Forbes, Elizabeth, Longley, John, Miller, Mark L., Spoerner, Michael, Marshall, Elaine

Journal:

Year:

2015

Language:

english

File:

PDF, 99 KB

english, 2015

35

High pressure31P NMR spectroscopy on guanine nucleotides

Spoerner, Michael, Karl, Matthias, Lopes, Pedro, Hoering, Marcus, Loeffel, Karoline, Nuehs, Andrea, Adelsberger, Joseph, Kremer, Werner, Kalbitzer, Hans Robert

Journal:

Journal of Biomolecular NMR

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

36

Pressure response of 31 P chemical shifts of adenine nucleotides

Karl, Matthias, Spoerner, Michael, Pham, Thuy-Vy, Narayanan, Sunilkumar Puthenpurackal, Kremer, Werner, Kalbitzer, Hans Robert

Journal:

Biophysical Chemistry

Year:

2017

Language:

english

File:

PDF, 666 KB

english, 2017

37

Flüssig-flüssig-Gleichgewichte in den binären Systemen aus Epichlorhydrin und Epibromhydrin mit n-Hexan und n-Heptan

Becker, Friedrich, Kiefer, Michael, Rhensius, Peter, Spoerner, Albrecht, Steiger, Alfred

Journal:

Zeitschrift für Physikalische Chemie

Year:

1978

File:

PDF, 1.68 MB

1978

38

ChemInform Abstract: LIQUID-LIQUID EQUILIBRIUMS IN BINARY SYSTEMS OF EPICHLOROHYDRIN AND EPIBROMOHYDRIN WITH N-HEXANE AND N-HEPTANE

BECKER, F., KIEFER, M., RHENSIUS, P., SPOERNER, A., STEIGER, A.

Journal:

Chemischer Informationsdienst

Year:

1979

File:

PDF, 112 KB

1979